Enters state: From Kentucky, Wayne County, near Kenova.
Leaves state: Into Virginia, Greenbrier, near White Sulphur Springs.
Counties: Wayne Cabell, Putnam, Kanawha, Fayette, Raleigh, Summers, Greenbrier
Major Cities & Towns: Huntington, Charleston, Beckley, Lewisburg
Comments: The major east-west route across West Virginia, I-64 was also one of the last major interstate routes completed in the United States. The segment from I-77 at Beckley to the US 60 interchange at Sam Black Church was not finished until the late 1980s. Prior to that, thru traffic had to use mountainous US 60 between Sam Black Church and Charleston. I-64 shares the route with I-77 (the West Virginia Turnpike) between Charleston and Beckley. Future plans call for widening the route to three lanes in each direction between Huntington and Charleston.

Begins: At I-79, Monongalia County, near Morgantown.
Leaves state: Into Maryland, rural Preston County
Counties: Monongalia, Preston
Major Cities & Towns: Morgantown
Comments: I-68 was originally numbered US 48 and was built as Corridor E of the Appalachian Development Highway System. It was renumbered as an interstate route when the portion of US 40 east of Cumberland, Md., was upgraded to limited-access status. This route connects I-79 with I-70 and is a thru route for traffic from states to the west of West Virginia headed for Washington, D.C., and is also promoted as an alternative route to the Pennsylvania Turnpike.

Enters state: From Ohio, Ohio County, at Weeling.
Leaves state: Into Pennsylvania, Ohio County, east of Wheeling. Counties: Ohio
Major Cities & Towns: Wheeling
Comments: This major east-west interstate route cuts through the northern panhandle of West Virginia on its route from Utah to Maryland. It spawns West Virginia's only three-digit interstate, I-470.

Enters state: From Virginia, Mercer County, near Bluefield.
Leaves state: Into Ohio, Wood County, near Williamstown.
Counties: Mercer, Raleigh, Fayette, Kanawha, Jackson, Wood
Major Cities & Towns: Bluefield, Princeton, Beckley, Charleston, Ripley, Parkersburg.
Comments: West Virginia's major north-south interstate highway, I-77 also carries the West Virginia Turnpike from Princeton to Charleston, and I-64 from Beckley to Charleston. The Turnpike was a two-lane route that predated the interstate system, which was finally expanded to full interstate standards in the late 1980s.

Begins: At I-77, Charleston.
Leaves state: Into Pennsylvania, Monongalia County, north of Morgantown.
Counties: Kanawha, Roane, Clay, Braxton, Gilmer, Lewis, Harrison, Marion, Monongalia.
Major Cities & Towns: Charleston, Weston, Clarksburg, Fairmont, Morgantown.
Comments: This route, in conjunction with I-77 and US 19 (Appalachian Corridor L), funnels traffic from the Carolinas north into Pennsylvania and New York. It runs in mostly an east-west direction through rural territory after springing from I-77 in Charleston, then turns to the north near Sutton. In conjunction with I-64 and I-68, serves as part of a thru route from Kentucky and points west to Washington, D.C. and Baltimore.

Enters state: From Virginia, Berkeley County, south of Martinsburg.
Leaves state: Into Maryland, Berkeley County, north of Martinsburg.
Counties: Berkeley.
Major Cities & Towns: Martinsburg.
Comments: One of the busiest north-south interstates in the eastern United States slices through the eastern panhandle of West Virginia. The volume of traffic is such that West Virginia is considering adding an additional lane in each direction.

Enters state: From Ohio, Ohio County, at Wheeling.
Ends: At I-70, Ohio County, at Wheeling.
Counties: Ohio.
Major Cities & Towns: Wheeling.
Comments: West Virginia's only three-digit interstate route, I-470 offers thru I-70 traffic a bypass of downtown Wheeling.